- Is caffeine high in histamine?
- The link between caffeine and histamine
- Intolerance to coffee vs. allergy to caffeine
- Symptoms of histamine or caffeine intolerance
- Is caffeine high in histamine: signals from the body
- How to reduce caffeine intake without suffering in the attempt
- Low histamine alternatives to coffee
- Does caffeine have a high histamine content?
- Listen to your body
Is caffeine high in histamine?
Over 2 billion cups of coffee are drunk every day around the world. This raises an important question for people with food sensitivities: is caffeine high in histamine? Given that the average adult in the United States drinks two cups a day, we should find out. And not just out of curiosity, but for our health.

Many people believe that coffee has many benefits for the body. It may lower the risk of cancer, heart failure, and type 2 diabetes. However, some people with histamine intolerance have reported adverse reactions to coffee.
I have felt it myself: a cup of coffee in the morning can lead to a headache and anxiety later. Coincidence? Maybe not.
The link between caffeine and histamine
How caffeine and histamine interact

So, is coffee high in histamine? Of course, the straightforward answer to this question is “yes”. Caffeine is high in histamine, and coffee (unless you drink it decaffeinated) contains a lot of caffeine. The relationship between histamine and caffeine, and their mutual influence, is quite complex.
Caffeine not only contains histamine directly, but can also interfere with the body’s ability to break it down. This is because it can slow down the enzyme diamine oxidase (DAO). This enzyme helps break down histamine in the body.
Hidden link that could explain coffee sensitivity
Researchers have noticed that histamine can boost the effects of caffeine. This might explain why some people react strongly to a small dose. It is a feedback relationship.

Histamine makes you more sensitive to caffeine. At the same time, caffeine stops histamine from breaking down properly.
Has it ever happened to you that after a coffee you feel nervous, with reddened skin or palpitations? It may not just be the stress of the day… but a biological response.
Intolerance to coffee vs. allergy to caffeine
What is the difference?
Here it is important to distinguish between coffee intolerance and caffeine allergy. Although their symptoms can be confused, the root of the problem is different:


Intolerance to coffee
Occurs when the body has problems to process the compounds of coffee. It is not an immune reaction, but it can cause annoying symptoms. These symptoms include headaches, skin rashes, fatigue, or digestive issues. This is usually due to irritants such as histamine, mycotoxins or biogenic amines present in coffee.
Caffeine allergy
In this case, the immune system goes into action, treating caffeine as an invader. Symptoms can be more severe and immediate: hives, difficulty breathing, tingling or even anaphylaxis.
Have you ever wondered if your reaction to coffee is immediate or occurs over time? That detail can help you understand if you are facing an allergy or an intolerance.
Symptoms of histamine or caffeine intolerance
Many symptoms of caffeine allergy and histamine intolerance are similar. This makes it hard to know which one you have. Personal experience plays a role here. In my case, a combination of anxiety, tachycardia and subsequent fatigue was the clue.

The most common symptoms include:
- Tachycardia
- Nervousness or anxiety
- Concern
- Headache
- Insomnia
- Urticaria
- Abdominal pain
- Congestion
- Fatigue
- Rashes or acne
- Numbness
- And in severe cases: anaphylaxis.
Is caffeine high in histamine: signals from the body

The short answer we already know, but the long answer depends on how your body reacts. I used to think that occasional insomnia was just due to stress. Then I noticed it happened after I had a strong cup of coffee in the afternoon.
Have you tried keeping a diary to track your symptoms? It might help you notice patterns invisible to the naked eye.
How to reduce caffeine intake without suffering in the attempt
Strategies for giving up coffee (without crying in the process)
Cutting back on caffeine is important if you have a caffeine allergy. It can also help if you have caffeine sensitivity or histamine intolerance.
The key is to do it gradually. Sudden withdrawal can cause withdrawal symptoms: headaches, fatigue, irritability. If coffee is part of your daily routine, switching to decaf or milder types can be a good first step.



You can also try with:
- Black tea (60 mg caffeine)
- Green tea (40 mg of caffeine)
- Caffeine-free herbal infusions, such as rooibos or chamomile
Note: If you cut back on caffeine because of histamine, remember that some teas also have high histamine levels.
Low histamine alternatives to coffee
If you want to avoid coffee because of histamine intolerance, there are ways to boost your energy without caffeine.
One interesting alternative is raw cocoa. While chocolate is high in histamine, raw cocoa might be friendlier. It has less histamine, plus it provides a smoother, longer-lasting energy boost.



Also gaining ground are beverages such as:
- Chicory coffee
- Adaptogenic infusions (with ashwagandha or reishi)
- Matcha low in histamine (although tolerance varies per person)
Does caffeine have a high histamine content?
We have already made it clear that it does. But it’s not the only one: you also have to be careful with:



- Caffeinated soft drinks
- Energy drinks
- Green and black tea
- Cocoa and chocolate
- Citrus juices
- Alcohol
Listen to your body

Each organism is unique. A cup of coffee may be energizing for one and unpleasant for another. The key is to listen to the signals your body gives you, inform yourself and make conscious decisions.
How about you? How does your body react to coffee? Could histamine be playing a role in how you feel?
FAQ
If you are on a strict low-histamine diet, it is best to avoid coffee. If you want to lower histamine, decaffeinated coffee or an occasional cup could be a good choice.
No. Coffee does not act as an antihistamine; in fact, it can increase histamine levels due to its caffeine content.